Transcriptome analysis of human autosomal trisomy
نویسندگان
چکیده
منابع مشابه
Transcriptome analysis of human autosomal trisomy.
We present transcriptome analyses of primary cultures of human fetal cells from pregnancies affected with trisomy 21 (t21) and trisomy 13 (t13). Pooled mRNA samples from t21 and t13 cases were used for comparative hybridizations to cDNA arrays with pooled mRNA from normal cells. When the array cDNAs were grouped by chromosomal location the relevant trisomic chromosome could be clearly identifie...
متن کاملAn autosomal trisomy in cattle
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متن کاملDouble Autosomal Trisomy and Mosaicism
There have been relatively few reports of individuals with double autosomal trisomy (Gagnon et al., 1961; Becker, Burke, and Albert, 1963; Hsu et al., 1965; Marks, Wiggins, and Spector, 1967). There have been rather more published accounts of individuals showing trisomy for one autosome and an additional chromosome in the sex chromosome complement as well. Of these, only those with the sex chro...
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The patient, a male, the seventh child of a 37-year-old father and a 34-year-old Caucasian mother, was the product of a pregnancy complicated by massive polyhydramnios. The mother previously had had two miscarriages. During the present pregnancy she had not had any infections or X-irradiation. There was no family history of congenital malformations, mental retardation, leukaemia, autoimmune dis...
متن کاملMassive-Scale RNA-Seq Analysis of Non Ribosomal Transcriptome in Human Trisomy 21
Hybridization- and tag-based technologies have been successfully used in Down syndrome to identify genes involved in various aspects of the pathogenesis. However, these technologies suffer from several limits and drawbacks and, to date, information about rare, even though relevant, RNA species such as long and small non-coding RNAs, is completely missing. Indeed, none of published works has sti...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2002
ISSN: 1460-2083
DOI: 10.1093/hmg/11.26.3249